Category Archives: Drug-Drug Interactions

Lower dosages of risperidone needed in older patients co-treated with perazine for ascariasis or pinworm?



If you have kept up with the pharmacokinetics of risperidone, your answer to the question in our title will likely be “Yes.” An anthelminthic prescribed for ascariasis and pinworm species in animals and man and an early (late Fifties era with some persistence to that of today), antipsychotic, perazine has been reported to inhibit CYPs 2D6 and 3A4, … Read the rest

Lower escitalopram dosages needed when acid pump inhibitors added?                           

That commonly used, non-prescription acid  pump inhibitors, such as omeprazole (Prilosec) and esomeprazole (Nexium) (both, inhibitors of CYP2C19) may increase the bioavailability of escitalopram (Lexapro) (a substrate of CYP2C19) is suggested by the findings of a simply designed, well-executed study by Norwegian researchers (G. Gjestad and colleagues, Therapeutic Drug Monitoring 37(1):90-97, 2015).

Having been adverted by a handful … Read the rest