Category Archives: Clinical Pharmacokinetics

Methylphenidate bioavailability increased by alcohol

This four-way, unblinded, uncontrolled comparison by University of Michigan pharmacist H.J. Zhu and colleagues (from the University of South Carolina, Medical University of South Carolina, and the University of Tennessee) (H.J. Zhu and colleagues, Journal of Clinical Psycho- pharmacology 37(4): 419-428, 2017) regretably suffers from a lack of blindedness and placebo control that its torturously long discussion leaves unassuaged.

The … Read the rest

Vortioxetine pharmacokinetics, writ small and large


This review of the pharmacokinetics of vortioxetine (G. Chen and colleagues, Clinical Pharmacokinetics 57:6:673-686, 2018), approved for treatment of depression and withal alleged to enhance cognition by increasing alertness, reminds us of how useful clinically can be knowing how long it takes for peak blood concentrations to fall by half (elimination half-life), how long is required for drug blood … Read the rest